Contribution of activated platelets to plasma IL-27 levels

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Contribution of activated platelets to plasma IL-27 levels

a r ecent issue of Critical Care, Wong and colleagues [1] demonstrated that the serum concentration of IL-27 in critically ill children was a predictor of infection. Our study aims at determining whether platelet activation contributes to the elevated plasma IL-27 concentration. Here we demonstrate that activation of platelets with thrombin receptor activating peptide (TRAP) significantly incre...

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Background: Effector CD4+ T cell subsets play an important role in Multiple Sclerosis (MS). Interleukin-27 (IL-27) suppresses Th (Th1, Th2 and Th17) cells and dampens autoimmunity and tissue inflammation by promoting the generation of Type 1 regulatory T cells (Tr1). Objective: To identify the relative levels of IL-27 and IL-17A in MS disease. Method: In a case-control study, venous blood was c...

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Interaction of platelet plasma membranes with thrombin-activated platelets.

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ژورنال

عنوان ژورنال: Critical Care

سال: 2013

ISSN: 1364-8535

DOI: 10.1186/cc11925